Correction of MR kappa-space data corrupted by spike noise

Magnetic resonance images are reconstructed from digitized raw data, which are collected in the spatial-frequency domain (also called kappa-space). Occasionally, single or multiple data points in the k-space data are corrupted by spike noise, causing striation artifacts in images. Thresholding methods for detecting corrupted data points can fail because of small alterations, especially for data points in the low spatial frequency area where the k-space variation is large. Restoration of corrupted data points using interpolations of neighboring pixels can give incorrect results. We propose a Fourier transform method for detecting and restoring corrupted data points using a window filter derived from the striation-artifact structure in an image or an intermediate domain. The method provides an analytical solution for the alteration at each corrupted data point. It can effectively restore corrupted kappa-space data, removing striation artifacts in images, provided that the following three conditions are satisfied. First, a region of known signal distribution (for example, air background) is visible in either the image or the intermediate domain so that it can be selected using a window filter. Second, multiple spikes are separated by the full-width at half-maximum of the point spread function for the window filter. Third, the magnitude of a spike is larger than the minimum detectable value determined by the window filter and the standard deviation of kappa-space random noise.     

Radiorecovery Activity of Dicopper(II) Tetrakis(3,5-Diiso propylsalicylate) Includes Recovery of Radiation-Induced Loss of Body Mass and Impaired Mouse Locomotion

Dicopper(II) tetrakis(3,5-diisopropylsalicylate), [Cu(II)(2)(3,5-DIPS)(4)], is effective in increasing survival of lethally irradiated mice when it is administered after irradiation. The possibility that this radiorecovery activity might also facilitate recovery from radiation-induced impaired increase in body mass and locomotion was examined. Cu(II)(2)(3,5-DIPS)(4) was used to treat LD 50/30 gamma irradiated female C57BL/6 mice after irradiation. A dose of 0, 5, 10, or 20 mumol Cu(II)(2) (3, 5-DIPS)(4) /kilogram of body mass was administered subcutaneously 3 hrs after LD 50/30 irradiation and change in body mass and locomotor activity measured daily throughout the 30 day post-irradiation period. Treatment with 5, 10, or 20 mumol Cu(II)(2) (3,5-DIPS)(4) /kg of body mass increased survival, which was statistically significant for the 10 mumol /kg of body mass-treated group compared to the vehicle-treated group (P<0.05), significantly (P<0.05) increased recovery of locomotion from days 13 to 15 post-irradiation onward for all treated groups compared to vehicle-treated mice, and increased recovery of body mass gain from day 14 onward for the 20 mumol /kg of body mass-treated group (P<0.001) and day 21, although not statistically significant, for the 10 mumol /kg of body mass-treated group. There were no statistically significant differences between the increase in survival, recovered increase in body mass, and recovered increase in locomotion for mice treated with 10 mumol or 20 mumol Cu(II)(2)(3,5-DIPS)(4) /kg on day 30 post-irradiation. It is concluded that Cu(II)(2)(3,5-DIPS)(4) in addition to increasing survival of irradiated mice increases the rate of recovery of radiation-induced decrease in body mass and locomotion.     

Comparison of amperometric methods for detection of exocytosis from single pancreatic beta-cells of different species

Two methods for amperometric detection of exocytosis at single pancreatic beta-cells were compared. In the first, direct detection of insulin was accomplished using an insulin-sensitive chemically modified electrode. In the second, 5-hydroxytryptamine (5-HT) that had been allowed to accumulate within the beta-cell secretory vesicles was detected with a bare carbon electrode. The goal of the comparison was to determine whether 5-HT secretion was a valid marker of insulin secretion in single beta-cells. To aid in this comparison, some experiments involved simultaneous measurement of insulin and 5-HT at cells previously allowed to accumulate 5-HT. Upon application of common insulin secretagogues, current spikes resulting from detection of 5-HT, insulin, or both compounds were obtained indicative of secretion via exocytosis. The mean area of current spikes obtained from simultaneous measurements equaled the sum of the mean area of insulin and 5-HT measured independently. Additionally, analyses of the number of spikes obtained for detection of insulin, 5-HT, or both compounds were similar for several common secretagogues. These data support the hypothesis that accumulated 5-HT is released from insulin containing secretory vesicles, exclusively. In addition, measurement of insulin and 5-HT from beta-cells of different species was compared to determine whether a species dependence exists for the two methods compared here. Detection of 5-HT results in a similar number of spikes that are equivalent to insulin in frequency and amplitude in human, porcine, and canine beta-cells; however, in mouse and INS-1 beta-cells, 5-HT is more readily detected than insulin.     

Fabrication of a multichannel wavelength-division multiplexing-passive optical net demultiplexer with arrayed-waveguide gratings and diffractive optical elements

A novel, to our knowledge, integrated wavelength-division multiplexing-passive optical net demultiplexer that uses an arrayed-waveguide grating and diffractive optical elements is presented. The demultiplexer is used to distribute 1.3-mum wavelength signals and to multiplex an eight-channel wavelength-division multiplexer spectrum at a 1.55-mum wavelength. The device shows high functionality and good optical performance. The measured cross talk was less than -21 dB, and the 3-dB bandwidth was determined to be 97 GHz, which is close to the theoretical value of 93 GHz. Average losses of 4.5 and 8 dB were measured for the 1.3- and the 1.55-mum signals, respectively.     

Measurements of the atmospheric carbon monoxide column with a ground-based length-modulated radiometer

A ground-based remote sounding instrument that uses a length-modulated radiometer to measure the total atmospheric carbon monoxide (CO) column has been built. Measurements made in Toronto during August and September of 1994 showed average CO concentrations of 125 to 150 parts per billion in volume (ppbv, parts in 10(9)). Similar measurements made in October at a rural site 80 km north of Toronto showed concentrations of approximately 100 ppbv. The latter measurements are shown to agree with other simultaneous ground- and satellite-based measurements. This instrument is an advanced prototype of the MOPITT (Measurements of Pollution in the Troposphere) satellite instrument.     

Unidirectional single-mode Nd:YAG laser with a planar semimonolithic ring cavity

Unidirectional single-mode operation of a diode-pumped Nd:YAG laser with a planar semimonolithic ring cavity has been demonstrated at 1064 nm. The semimonolithic cavity consists of a laser active medium placed in a magnetic field, a crystal quartz plate, and an output coupling mirror, which form an optical diode by acting as a Faraday rotator, a reciprocal polarization rotator, and a partial polarizer, respectively. A single-mode output power of 155 mW and a slope efficiency of 17% were obtained with a 1.2-W diode laser at 809 nm. A laser linewidth of less than 100 kHz is inferred from a beat note frequency spectrum between two identical laser systems and continuous tuning to greater than 2 GHz was observed.     

Respiratory motion of the heart from free breathing coronary angiograms

Respiratory motion compensation for cardiac imaging requires knowledge of the heart's motion and deformation during breathing. This paper presents a method for measuring the natural tidal respiratory motion of the heart from free breathing coronary angiograms. A three-dimensional (3-D) deformation field describing the cardiac and respiratory motion of the coronary arteries is recovered from a biplane acquisition. A cardiac respiratory parametric model is formulated and used to decompose the deformation field into cardiac and respiratory components. Angiograms from ten patients were analyzed. A 3-D translation motion model was sufficient for describing the motion of the heart in only two patients. For all patients, the heart translated caudally (mean, 4.9+/-1.9 mm; range, 2.4 to 8.0 mm) and underwent a cranio-dorsal rotation (mean, 1.5 degrees+/-0.9 degrees; range, 0.2 degrees to 3.5 degrees) during inspiration. In eight patients, the heart also translated anteriorly (mean, 1.3+/-1.8 mm; range, -0.4 to 5.1 mm) and rotated in a caudo-dextral direction (mean, 1.2 degrees+/-1.3 degrees; range, -1.9 degrees to 3.2 degrees).